The headache after long-distance running is related to long-distance running and strenuous activities, but the headache can be relieved quickly after resting. Long-distance running may cause changes in the patient’s breathing rhythm, which may lead to carbon dioxide retention in the body and cause headache symptoms. Blood pressure may also fluctuate during long-distance running, resulting in an increase in blood pressure, which may also cause headaches. Patients are advised to rest slowly and can massage on the head or use ice on the head, the headache can be relieved quickly. Patients are advised to exercise in moderation and not to overload, especially for those who are often inactive, and not to suddenly run long distances or perform activities of excessive intensity, as this can easily induce acute cardiovascular and cerebrovascular problems.