I. World Health Organization (WHO) definition: According to the World Health Organization (WHO) definition, a diabetic foot is a foot infection, ulcer and/or deep tissue destruction associated with local nerve abnormalities and peripheral vascular lesions in the distal lower extremity. The International Diabetic Foot Working Group defines a diabetic foot ulcer as a trauma to the cumulative total skin below the ankle in diabetic patients, independent of the duration of such trauma. Approximately 80% or more of amputations in diabetic patients are due to diabetic foot ulcers. Therefore, prevention and control of foot ulcers is the most important measure to reduce the rate of diabetic amputation. Second, the epidemiology of diabetic foot: some data show that 10%-15% of diabetic patients will occur diabetic foot ulcers. Among them, 10%-14.5% of patients will be amputated, and the amputation rate of diabetic patients is 10 times that of non-diabetic patients. The physical and mental health of patients is extremely dangerous. As of 2002, the incidence of diabetic foot in China ranks second only to India in developing countries. Diabetic patients are 25 times more likely to have an amputation than non-diabetic patients, 70% of amputations occur in diabetic patients, and every 30 seconds someone loses a leg because of diabetes! Third, the common clinical manifestations of diabetic foot: (1) the general performance of the foot: dry and non-sweaty skin of the affected limb, tingling, burning pain, numbness, dullness or loss of sensation, sock-like changes, feet on cotton wool sense; muscle atrophy, arch foot, mallet toe, chicken claw toe and other foot deformities. When the patient’s bones and joints and surrounding soft tissues are damaged by strain, the patient continues to walk, which may cause multiple fractures and ligament rupture, resulting in Charcot joint (Charcot). (2) The main manifestations of ischemia: common skin dystrophy muscle atrophy, dry skin with poor elasticity, detachment of hair, decreased skin temperature, pigmentation, weakening or disappearance of arterial pulsation at the extremities, the most typical symptoms are intermittent claudication, rest pain, difficulty in squatting and standing up. When the patient has a break in the skin of the affected limb or spontaneous blistering after being infected, ulcers, gangrene or necrosis are formed. (3) Diabetic foot ulcers are divided into neurological ulcers, ischemic ulcers and mixed ulcers according to the nature of the lesion. A neuropathic ulcer foot is usually warm, numb, dry, with little pain and good fluctuation of the arteries in the foot. A foot with concurrent neuropathy can have two consequences: neuropathic ulcers (mainly on the sole) and neuropathic arthropathy (Charcot joint). Foot ulcers due to ischemia alone are rare. In neuro-ischemic ulcers these patients have both peripheral neuropathy and peripheral vasculopathy. The dorsalis pedis artery fluctuations are absent. The feet of these patients are cold and may be associated with pain at rest, ulceration and gangrene at the edges of the foot. Fourth, the comprehensive treatment of diabetic foot in the Department of Endocrinology and Metabolism of Nanfang Hospital: diabetic foot is a common and complex chronic complication of diabetes that consumes high medical expenses and is difficult to treat. The Department of Endocrinology and Metabolism of Southern Hospital adopts active and effective preventive evaluation measures, and diabetic foot evaluation is performed at least once a year for diabetic patients with risk factors to detect predisposing factors for ulcers and amputations (neuropathy, vascular lesions and deformities) at an early stage. Through comprehensive and systematic examination and assessment of risk factors, patient education, and reasonable and unique comprehensive treatment techniques, the amputation rate of diabetic foot patients has been greatly reduced, and the cure rate ranks among the highest in China. V. Diabetic foot: prevention is more important than treatment: 1. Control blood sugar and take good care of the feet. 2, pay attention to the details, do not burn your feet. 3, elderly patients, be vigilant. 4.Regular checkups and more medical consultations.