If the 24h urine protein quantification of 500mg is caused by physical factors such as strenuous exercise and stress, it is usually not serious. If caused by glomerulonephritis, diabetic nephropathy and other diseases, it is more serious. Normal people 24h urine protein quantitative should be less than 150mg, so 24h urine protein quantitative 500mg more than the normal value range, belong to abnormal phenomenon. If it is clear that the 24h urine protein quantitative 500mg is caused by physical factors such as strenuous exercise, tension, etc., it will return to normal after proper rest and adjustment of the mindset, which is usually not serious, and there is no need to worry too much. Some 24h urine protein quantitative 500mg is caused by glomerulonephritis, diabetic nephropathy, systemic lupus erythematosus and other diseases. Usually, the disease will cause patients to have uncomfortable symptoms, which will affect the quality of life and health, so it is more serious. If the patient does not pay attention to it and actively cooperate with the doctor, it will lead to aggravation of the condition and affect the prognosis. It is recommended that people with 24h urine protein quantification of 500mg should consult a regular hospital for further detailed examination, and if it is clear that it is caused by the disease, they should actively cooperate with the doctor for treatment.