Pharmacological effects of glucocorticoids

The pharmacological effects of glucocorticoids mainly affect the metabolism of sugar and protein, and have anti-inflammatory and anti-allergic effects, but have less effect on water and salt metabolism. The main effects are: i. Anti-inflammatory effects, which are non-specific and have significant inhibitory effects on different stages of various types of inflammation. The anti-inflammatory effect may be through the following mechanisms: 1. inhibition of granulocyte and macrophage migration outside the blood vessels, reducing the inflammatory invasive tissue response. 2. inhibition of inflammatory capillary dilation, reducing capillary wall permeability and edema formation. 3. stabilization of lysosomal membranes to reduce, the release of hydrolases from lysosomes, thus reducing damage to tissues. 4. inhibition of the process of DNA synthesis in granulosa cells. Second, is the anti-immune effect. Third, the anti-toxic effect. IV. Anti-shock effect. V. Effects on blood. VI. Central action.