Unilateral enlarged tonsils that do not subside and hot feeling in the throat may be caused by leukemic pharyngitis, tonsil cancer, lymphoma, etc. Drugs, surgery, radiotherapy, chemotherapy, etc. should be carried out according to the cause of the disease. 1. Leukemic pharyngitis: in the early stage, one side of tonsil is congested and enlarged, and in the acute stage, there is often a rise in body temperature and a feeling of heat in the throat. At present, there are mainly the following treatment methods: chemotherapy, radiotherapy, targeted therapy, immunotherapy, stem cell transplantation and so on. 2. Tonsillar cancer: Tonsillar cancer can be manifested as unilateral or bilateral tonsillar enlargement that does not subside, with heat sensation and accompanied by severe pain and difficulty in swallowing. Treatment is mainly based on surgery, radiotherapy and chemotherapy, and appropriate treatment plan should be chosen according to patients’ specific conditions. 3. Lymphoma: lymphoma mainly takes enlarged lymph nodes as the main manifestation, and some people with enlarged lymph nodes in neck or supraclavicular lymph nodes may also be accompanied by unilateral or bilateral enlarged tonsils which do not subside and accompanied by heat sensation of larynx, etc. The treatment is mainly chemotherapy and radiotherapy. Treatment is mainly based on chemotherapy and radiotherapy, with chemotherapy and radiotherapy for Hodgkin’s lymphoma and chemotherapy for non-Hodgkin’s lymphoma. It is suggested that patients should consult a doctor in time and be diagnosed and treated by a professional doctor, and the above medicines should be used under the guidance of a doctor.