Herpes zoster on the hands can be treated with topical and oral medications. Herpes zoster is a disease that affects the nerves and skin, caused by varicella zoster virus, manifested as papules or blisters on the surface of the skin, mostly accompanied by obvious pain. 1. Topical medication: Topical antiviral creams, such as acyclovir cream, ganciclovir cream, penciclovir cream, interferon gel, etc., can be applied to the blisters and breakouts. 2. Oral medications: Oral medications include antiviral drugs, such as acyclovir tablets, vasiclovir hydrochloride tablets, etc.; pain relievers, such as acetaminophen tablets, gabapentin capsules; and nutritive neurotoxic drugs, such as methylcobalamin tablets, vitamin B1, etc. All of the above medications have adverse effects, and it is recommended to apply them to the blisters and ulcers. All of the above drugs have adverse reactions and are recommended to be used under the guidance of a doctor. If you have shingles on your hands, it is recommended that you go to the hospital in time and avoid touching or scratching the rash with your hands during the treatment period to prevent spreading the virus through hand contact.