Breast cancer chemotherapy for the first time hair loss and headache, mainly is the adverse reaction of chemotherapy drugs, you can take painkillers under the guidance of the doctor to relieve headache, stop or change chemotherapy drugs. 1. Headache during chemotherapy, you can take acetaminophen, ibuprofen and other drugs to relieve pain. 2. Commonly used chemotherapy drugs for breast cancer include cytarabine, cyclophosphamide, cisplatin, paclitaxel, fluorouracil, etc. If headache, hair loss and other adverse reactions occur in the course of chemotherapy, it is recommended to stop or replace the chemotherapy drugs under the guidance of the doctor in a timely manner, and it is not recommended to stop or replace the drugs without authorization. The use of drugs combined with their own specific situation, drug allergy is prohibited.