Amiodarone is an antiarrhythmic drug, the most serious side effects are adult respiratory distress syndrome, arrhythmia and even cardiac arrest, but the chance of occurrence is low, the specific use of the drug should follow the doctor’s instructions. Amiodarone is a kind of antiarrhythmic drug, can prolong the action potential and effective response period of the heart muscle, eliminate the refractory excitation, can be used for the treatment of atrial, nodal, ventricular arrhythmia and arrhythmia with W-P-W syndrome, and so on. There are individual differences in the use of amiodarone, and the most serious side effects include respiratory distress syndrome in adults, worsening of cardiac arrhythmias and even cardiac arrest, visual impairment and visual dysfunction, fetal toxicity, and liver injury. Other side effects include abnormal thyroid function, congestive heart failure, nausea, vomiting, constipation, solar dermatitis, insomnia, dizziness and headache. Amiodarone should not be used in patients with sinus bradycardia without pacemaker, sick sinus node syndrome, severe atrioventricular block, hyperthyroidism, as well as pregnant and lactating women. The drug should be used under the guidance of a doctor and in strict compliance with the doctor’s instructions to avoid adverse reactions, and if there is any discomfort in its use immediately seek medical attention.