Hepatitis B nausea, fatigue is great, should be tested as soon as possible liver function, liver ultrasound and other items, to understand the condition of the liver, if necessary, to give antiviral, hepatoprotection, antifibrotic and other drug treatment. Mild, moderate, severe hepatitis B can appear nausea, fatigue symptoms, mostly suggesting that liver function is impaired, hepatocyte degeneration, necrosis, liver function, hepatitis B virus DNA quantitative testing, liver ultrasound and other tests should be carried out as soon as possible, to understand the function of the liver, whether there is liver fibrosis and other conditions. Clinical treatment should be given according to the specific conditions of patients, such as application of interferon α, tenofovir and other antiviral treatment, maximum long-term inhibition of viral replication; application of reduced glutathione and other hepatoprotective drugs, bisabolol and other enzyme-lowering drugs, Yin gardenia yellow and other drugs to improve and restore liver function; application of γ interferon and other anti-hepatic fibrosis, etc., and the process of treatment should be well monitored and followed up. Hepatitis B patients should have a correct view of the disease, have patience and confidence in hepatitis treatment, daily diet attention to light, nutritious, easy to digest, avoid alcohol, if there is any maladjustment in time to see a doctor for treatment.