Tic-tac-toe syndrome is a neurological disorder with many triggers. The disease is common in children between the ages of 2 and 15 years old, and is usually characterized by abnormal twitching or violent behavior. The most common symptoms are on the face and neck, and some are on the limbs. 2, the harm to patients: this disease may make the patient appear extremely low self-esteem, can not work and live well, long-term failure to relieve may appear psychological disease this symptom will also induce obsessive-compulsive disorder, but also attention deficit and hyperactivity disorder, is a relatively difficult to cure the symptoms, need long-term gradual treatment. 3, the disease’s most prevalent group: generally in the 4 to 12-year-old boys are more common in this disease, patients will appear nervous anxiety, energy can not focus, will appear learning difficulties emotional disorders, will appear blinking squinting and many other abnormal movements, must be treated as soon as possible. If a child has abnormal body movements, sometimes very subtle, such as blinking more frequently, it could be tic-tac-toe syndrome and should be taken seriously. Each child has different symptoms, it is still important to find abnormalities and go to the hospital early.