Neonatal jaundice up to 23 is already very serious. The cause of jaundice will be further screened for infectious jaundice, and if infectious, antibiotics will be needed; if hemolytic jaundice is present, it is recommended to apply propylene glycol to reduce the hemolytic reaction. In addition, we will determine whether the index of blood exchange has been reached according to the value of total bilirubin. If the index of blood exchange is reached, further blood exchange combined with phototherapy is recommended to reduce jaundice. If the jaundice is so high, it is possible that the bilirubin has entered the head, causing bilirubin encephalopathy, which will appear to reduce milk consumption, poor response, cramps, drowsiness, increased muscle tone and other abnormalities, if these conditions, you need to be alert, the baby recommended further MRI and auditory brainstem response to further clarify, if there are abnormalities, the future should be regularly followed up to check.