Closed mouth acne, or whitehead acne, on the brain can be removed through life management, medication, photodynamic therapy, and fruit acid treatment. Whitehead acne is a white keratinized pimple with an epidermal covering that is not connected to the outside world and is closed. When there is whitehead acne on the brain, first of all, you need to pay attention to clean, avoid squeezing and scratching, avoid eating spicy and stimulating food. At the same time, after excluding contraindications, you can use topical adapalene gel, benzoyl peroxide, azelaic acid, erythromycin and other drugs, and/or oral minocycline, doxycycline, isotretinoin and other medications for treatment, and the use of the drugs are required to be carried out under the guidance of professional medical personnel. Photodynamic therapy and fruit acid therapy can also be used to remove whiteheads on the brain.