Patients with sudden itching and large bumps on the skin may be caused by mosquito bites, hives, eczema and other factors, and the symptoms can be relieved by medication and physical therapy. 1. Mosquito bites: patients may have itchy skin and bumps after being bitten by mosquitoes, and can use anti-allergy and anti-itch creams under the guidance of doctors, such as compound diphenhydramine cream, compound chlorpheniramine tincture, etc.; topical glucocorticosteroids, such as compound dexamethasone acetate cream, triamcinolone acetonide cream, etc.; antipruritic lotions such as glycerol wash and so on to carry on the treatment. 2. Urticaria: patients with urticaria can follow the doctor’s instructions to use antihistamines, such as loratadine, cetirizine, etc.; immunosuppressants, such as tacrolimus, etc.; H2-receptor antagonists, such as ranitidine, cimetidine, etc.; topical antipruritic drugs such as glycerine lotion, benadryl cream, etc. for treatment. 3. Eczema: Eczema patients can follow the doctor’s instructions to use topical drugs, such as glycerine lotion, 3% boric acid solution, hydrocortisone cream, dexamethasone cream, etc.; antihistamines, such as chlortetracycline, cetirizine, etc. for treatment. Glucocorticoids, prednisone, dexamethasone, etc., may be used in patients with severe disease. Patients can also improve their condition by means of ultraviolet radiation. Sudden itching of the skin with large bumps is recommended to consult a doctor in time to identify the cause, strictly follow the doctor’s prescription medication, and actively cooperate with the doctor’s treatment.