Fluconazole can be used for the treatment of fungal otitis externa, fungal otitis externa is preferred to be treated with topical antifungal drugs, specific medication as prescribed by the doctor. Fluconazole is a triazole antifungal drug, suitable for coccidioidomycosis, cryptococcal meningitis, invasive candidiasis, mucocutaneous candidiasis and other diseases. The drug can also be used for the treatment of fungal otitis externa, but fungal otitis externa is generally recommended to be treated with topical antifungal medication (e.g., miconazole nitrate cream) first, followed by oral antifungal medication if necessary. Fluconazole is contraindicated in people who are allergic to this product or other azoles, and common adverse reactions such as headache, abdominal pain, diarrhea, nausea, vomiting, elevation of transferases, and skin rash may occur after use of the drug. Specific medication should be under the guidance of a specialist, not unauthorized use of drugs. Fungal otitis externa patients are advised to seek timely medical treatment, follow the doctor’s instructions, do not self-medication, delay the condition.