(1) protect the tongue, it is best to wrap a gauze tongue depressor (or a homemade one about 20 cm long, 1.5-2 cm wide, 0.3-0.5 cm thick with rounded edges or bamboo plate) between the upper and lower molars of the patient to prevent the patient from biting his tongue during the spasms. If the aura period can not be put on, the tonic period when the patient opens his mouth should also be put in, to the spastic period should not be put in. The tongue depressor can also prevent the tongue from falling back and blocking the airway. Yang Zhongxu, Department of Neurosurgery, The First Affiliated Hospital of Tsinghua University (2) Quickly let the patient lie flat on the bed or lie down on a flat place nearby when an aura is found. If it is too late to make the above arrangement, when you find that the patient is going to fall, you should quickly hold the patient and let him/her fall down in a smooth manner to prevent him/her from suddenly falling down and injuring his/her head or body by himself/herself. (3) The patient’s head is mostly tilted back excessively during the tonic phase, and the jaw is over-extended, which can cause cervical compression fracture, or dislocation of the jaw. At this time, one hand should hold the patient’s occiput with slight force to prevent his neck from being over-extended, and one hand should hold the jaw to counteract his jaw over-extension. (4) There are more respiratory secretions during grand mal seizures, which can easily cause respiratory obstruction or aspiration pneumonia. From the beginning of a grand mal seizure, the patient’s head should be turned sideways to one side so that secretions can flow out naturally. In addition, it is better to unbutton the patient’s neck to keep the airway open. (5) During the spasm period, the muscles of the limbs contract, which can easily cause joint dislocation and limb abrasions. At this time, appropriate force can be pressed at the large joints of the limbs (such as shoulder, elbow hip, knee) to limit the amplitude of their jerking, at this time, avoid excessive force and forceful pressure, so as not to cause artificial injury or fracture of the muscles and joints. (6) Seizures should also be unbuckled their belts, and dentures should be removed when available. (7) After the grand mal seizure has stopped, the patient will take several minutes, tens of minutes or even hours to return to normal. Some patients are in a drowsy state during this time, so just let them sleep comfortably and quietly. Other patients are in a hazy state, the patient can appear some purposeless and unconscious impulses, destruction, aggressive behavior, sometimes self-injury, injury, suicide, murder, destruction, etc.. At this time, in addition to immediately giving the patient intramuscular or intravenous sedatives such as luminal or valium, the patient’s behavior should be strictly limited to ensure safety.