It is common to see patients with herpes zoster who have neuralgia after the rash has subsided. 90% of patients have pain induced by normal local skin irritation, such as friction from underwear, which is characteristic of postherpetic neuralgia. In patients with shingles, neuralgia that persists after the lesions have resolved should be followed up on an outpatient basis. If the neuralgia persists after the lesions have subsided, the patient should be followed up on an outpatient basis with appropriate medication, such as pregabalin or gabapentin, combined with nerve-nourishing drugs, oral methocobalamin and vitamin B1. Physiotherapy and electrophysiotherapy should be used to reduce the pain and improve the quality of life. If the pain is so severe that conventional treatment is ineffective, a pain consultation is required to assist in the diagnosis and treatment, and nerve blocks are more commonly used in clinical practice.