Pregnant women with epilepsy have an increased number of seizures in 45% of patients with epilepsy who are pregnant. This is mainly caused by fluid retention after pregnancy, accelerated metabolism of drugs in the liver, and increased susceptibility of fetal tissue and placenta, resulting in lower serum concentrations of antiepileptic drugs. The number of seizures and the increase in seizure severity are closely related to the degree of seizure control prior to pregnancy. Some statistics show that only 25% of those with no more than one seizure in the first 9 months of pregnancy had an increase in the number of seizures. Of course, there are cases where seizure control is instead better after pregnancy. Therefore, epileptic patients, it is important to prepare for pregnancy and achieve at least 1 year of strict control. Given that increasing the amount of antiepileptic drugs may have adverse effects on the mother and fetus, the blood concentration of epileptic drugs should be measured frequently after pregnancy, and if it is lower than the effective drug level, the dosage may be increased appropriately, but not blindly. The incidence of teratogenic fetuses with antiepileptic drugs is about 2.2% to 13.8%, and the common ones are cleft palate, cleft lip, heart anomaly, etc. The occurrence of teratogenicity is related to the mother’s age, family history of congenital malformation and diseases (such as diabetes) on the one hand, and the drugs used on the other. The only report of spina bifida is valproate, while no definite report of teratogenicity has been seen for carbamazepine. In general, the teratogenic risk of antiepileptic drugs is not too great, you cannot give up pregnancy simply because of this reason, and you should never give up treatment after pregnancy, otherwise epilepsy occurs frequently and is more harmful. In order to prevent the risk of teratogenic, should be well prepared before pregnancy, to more than 3 years of epilepsy control, drugs have been withdrawn or have been reduced after pregnancy is more appropriate, of course, can not be postponed to more than 35 years old, high age first birth, teratogenic risk increases. The dose should be reduced to the lowest possible level for seizure control. Patients or their relatives who have inherited malformations should be sterile. Patients who have had miscarriages, stillbirths or have delivered – abnormal babies in the past should be extra cautious when conceiving again.