If you feel a little pain in the middle of urination, it may be due to urinary tract infection, urinary tract stone or prostatitis, which can be treated with medication and surgery. 1. Urinary tract infection: If the bacterial infection leads to inflammation of the urinary tract, thus appearing in the middle of the urine to touch up the pain of the situation. You can follow the doctor’s instructions to use anti-infection drugs for treatment, such as ciprofloxacin, ofloxacin, etc., so as to relieve the pain. 2. Urethral calculi: If the patient has urethral calculi, the stone will lead to urinary tract obstruction, and there will be pain in the middle of urination. At this time, if the urinary tract stone is small, according to the doctor’s advice by drinking more water, exercise way to try to discharge. If the stones are large and cannot be discharged, they can be treated with surgery such as ureteroscopic lithotripsy. 3. Prostatitis: For prostatitis caused by bacterial infection, anti-infection treatment such as oral levofloxacin and cefixime is needed. For non-bacterial prostatitis, in addition to antimicrobials, alpha-blockers such as terazosin and M-blockers such as atropine can be used. The above drugs should be used under the guidance of a doctor. Painful urination may also be caused by other factors, which require different treatments. It is recommended that patients go to regular hospitals for timely consultation and treatment, and strive for early recovery.