Taking medicine does not work is suspected to be caused by the failure to treat the cause, the pathogenic bacteria are not sensitive to drugs, the condition is serious, need to adjust the treatment according to the actual situation. Sore throat, may be acute tonsillitis, stem overgrowth syndrome, upper respiratory tract infections and other diseases, need to take targeted treatment for different diseases. 1. Acute tonsillitis: mostly caused by type B hemolytic streptococcus infection, patients need to follow the medical advice to apply amoxicillin, ceftriaxone and other antibiotic drugs. At the same time, patients also need to follow the doctor’s instructions to apply the compound borax solution, compound chlorhexidine gargle, 1:5000 furacilin and other gargles. If the effect of medication is not good, according to the results of bacterial culture and drug sensitivity test to replace the sensitive antibiotics. 2. Stem overgrowth syndrome: this disease often occurs in the case of ineffective medication, can consider surgical treatment. 3. Upper respiratory tract infection: this disease is mostly caused by viral infections, when secondary bacterial infections often make the symptoms gradually aggravate, or need to choose targeted treatment according to the cause of the disease, such as the use of amoxicillin, blue scutellaria oral solution, swelling and pain in the capsule, or change the dosage form of the drug. In summary, the sore throat medication regardless of the need to go to the hospital in a timely manner, with the doctor to improve the examination, standardized medication and treatment, so as not to delay the condition.