Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that is caused by a series of uncomfortable symptoms and complications due to the regurgitation of gastric contents into the esophagus. It typically presents with heartburn, acid reflux, difficulty swallowing food or burning pain behind the sternum. Some patients may also suffer from foreign body sensation in the throat, hoarseness, chronic pharyngitis, chronic cough, chronic bronchitis or chronic asthma. Recent studies have found that patients with GERD also often experience sleep disturbances. In a recently published large-scale population-based survey in France, the prevalence of GERD was 8.3% among 36,663 people consulted, of whom 64.6% had nocturnal reflux and 58.6% awoke from a deep sleep due to heartburn; nocturnal awakenings, difficulty falling asleep, nightmares, daytime sleepiness and extraesophageal symptoms occurred more frequently among patients with nocturnal reflux, and the frequency of complaints about Those who complain most about lack of sleep are also more likely to have reflux during the day. Chronic sleep disorders can affect many aspects of a patient’s life, including daytime sleepiness, irritability, anxiety, inability to concentrate, and decreased productivity. In addition, severe GERD can be combined with gastrointestinal bleeding, esophageal strictures, ulcers, and even cancer, so those with these typical symptoms should go to the hospital promptly. Gastroscopy, upper gastrointestinal barium meal imaging, 24-hour esophageal pH monitoring, esophageal manometry, and esophageal bile reflux measurement are all helpful for the diagnosis of the disease. In daily life, the symptoms of mild cases can be relieved by a combination of lifestyle adjustments, dietary changes, increased exercise, weight loss, and control of reflux triggering factors. For example, elevating the head of the bed, reducing the intake of fatty foods, avoiding spicy diets, wearing less tight clothes, quitting smoking and alcohol, avoiding lying down 3 hours after meals, and minimizing the consumption of foods that can lower the pressure of the esophageal sphincter (such as chocolate, alcohol, peppermint oil, coffee, onions and garlic) can help improve patients’ nocturnal reflux and sleep disorders. For patients with more severe symptoms, medications can be taken under the guidance of a physician for adjunctive treatment. In addition, patients with complications should go to the hospital promptly. Patients who do not respond to medication or who relapse after stopping medication should be carefully treated with anti-reflux surgery.