Isosorbide mononitrate infusion headaches are primarily due to nitrate-induced vasodilation and consequent vasodilatory headaches.
Isosorbide mononitrate is a long-acting NO donor, clinically widely used in the treatment of coronary heart disease angina pectoris, infusion of isosorbide mononitrate produces headache is mainly due to the activation of guanylate cyclase in smooth muscle, inducing diastolic capillaries after the increase in cerebral vascular storage, but also dilated small arteries so that the meningeal vasodilatation, thus producing throbbing headache.
When infusion of isosorbide mononitrate headache, should promptly communicate with the doctor, and follow the doctor’s instructions to decide whether to continue to use the drug, generally the degree of headache is less severe, you can continue to infusion, if the headache symptoms are more serious, should be suspended infusion.