Elevated creatinine due to hyperuricemia usually recovers after prompt treatment in the acute phase, and is usually difficult to recover in the chronic phase (>3 months). Uric acid is the end product of purine metabolism, and impaired uric acid production and/or excretion can lead to hyperuricemia. Hyperuricemia can cause kidney damage such as acute uric acid nephropathy, chronic uric acid nephropathy and uric acid urinary stones, and is an independent risk factor for the progression of kidney disease. Elevated creatinine caused by hyperuricemia is in the acute stage (acute uric acid nephropathy), and renal function can be restored in most patients after active symptomatic or dialysis treatment. Hyperuricemia can cause or promote the progression of chronic kidney disease. Elevated creatinine caused by hyperuricemia is in chronic stage (>3 months), which is usually difficult to recover, and the treatment is mainly aimed at slowing down the progression of renal function and preventing the deterioration of renal function. Elevated creatinine caused by hyperuricemia should go to the hospital in time for consultation and active treatment under the guidance of professional physicians.