Hemoglobin electrophoresis is one of the diagnostic methods used to check for thalassemia. Hemoglobin electrophoresis is used to check for abnormal hemoglobin in the blood. A hemoglobin electrophoresis test reveals a special hemoglobin electrophoresis band in the abnormal hemoglobin, and in thalassemia there is a structural abnormality in the hemoglobin. Thalassemia is also called marine anemia, due to gene mutation caused by the synthesis of hemoglobin in the red blood cells is different, there are two common types of α and β. When doing hemoglobin electrophoresis, it will be found that the synthesis of the α and β which type is reduced, missing, you can determine the type of thalassemia, according to the amount of missing to determine the severity of the disease.