As a hepatobiliary and pancreatic surgeon, it is often painful to diagnose a new case of advanced pancreatic cancer of the tail of the pancreatic body. One is for the patients and their families who trust me, and the other is that as a hepatobiliary and pancreatic surgeon who has been practicing for many years and has returned from overseas studies, I cannot bring satisfactory answers such as radical treatment with surgical resection for my patients and their families who have hopeful hearts. Why are most of these tumors found to be advanced? There are generally three reasons! 1. There are no typical clinical symptoms and signs of this disease. In the early stage, it may be a vague pain and discomfort in the upper abdomen, sometimes light and sometimes heavy. It usually does not affect diet or rest. The anatomical location of the pancreas also leads to early lesions that are not easy to obtain clear imaging findings. For example, ultrasound may be disturbed by abdominal gas and cannot accurately detect pancreatic lesions. Considering the tediousness and high cost of CT examination, it cannot be used as a routine examination. 2. Patients or family members do not know about this disease. Generally, when upper abdominal discomfort appears in the early stage, they do not go to the hospital for outpatient examination in time. Instead, they only seek medical attention when they have severe abdominal pain or back pain, or when they cannot eat and ascites is formed. 3. The doctors in the hospital do not know enough about this tumor. Patients usually have upper abdominal discomfort, abdominal pain, bloating after eating or reduced eating when they visit the hospital. Sometimes, when they arrive at the hospital, they only perform barium meal examination and are satisfied with the diagnosis of gastritis or gastrointestinal ulcer, but ignore the back pain or unrelieved pain that may accompany the patient. Such examples are not uncommon. Depending on the cause, what we may do can only be improved for the third condition. If we consider the patient’s age (>40 years old), history of long-term alcohol consumption, epigastric pain with change in eating habits, especially back pain found, especially with nighttime aggravation; those who have no effect or worsening symptoms according to the treatment of gastrointestinal diseases, as a doctor, we must think of the possibility of pancreatic body caudal cancer and should further investigate to confirm the diagnosis. Patients and family members should also understand the importance of further examination, such as CT, and cooperate with us. In a certain sense, it is better to spend money without finding the tumor than to delay the diagnosis and treatment of the disease without CT and other examinations. But there is also an optimistic side. We are now working closely with our sister departments such as imaging, and have discussed more deeply the diagnosis and treatment of malignant tumors that are a serious threat to people’s health, and have carried out relevant targeted treatment. It has significantly reduced the pain of patients and improved their quality of life. However, the long-term efficacy of the treatment has yet to be clarified by further research.