Hepatitis B major triple-positive with abnormal liver function indicates that hepatitis B is in the active stage and requires relevant treatment. Usually after aggressive treatment, the patient’s condition will gradually stabilize and the life expectancy will be the same as that of a normal person. For active hepatitis B, the most important treatment is antiviral therapy. The drug of choice is usually entecavir or tenofovir, which needs to be taken for a long time, at least 4 years, and some people even need to take it for life. If the liver function transaminase is relatively high, you need to use appropriate liver-protecting and enzyme-lowering drugs, and you need to pay attention to rest, light diet, do not stay up late, and pay attention to monitoring the changes in liver function. In a few patients with severe hepatitis, the success rate of treatment is reduced.