Whether or not to take tetanus vaccine after being stabbed by a nail should be judged according to the severity of the wound. Generally speaking, if the wound is shallow or not bleeding, it can be sterilized with iodine; if the wound is deeper, an anaerobic environment will be formed inside the wound, which will easily cause Clostridium tetani to multiply and cause tetanus. Tetanus is a disease caused by Clostridium tetani that invades the human body through the skin and mucous membranes and then reproduces and secretes toxins in an anaerobic environment, resulting in persistent tonicity and paroxysmal spasms of the skeletal muscles, and in severe cases, even asphyxiation and respiratory failure, leading to death. Tetanus shot refers to the tetanus vaccine made from the toxin produced by the culture of tetanus bacillus strains, and after vaccination, the body can be made to produce a humoral immune response, which is used to prevent tetanus. In summary, a nail should be immediately sterilized in a hospital and a doctor’s evaluation should determine if a tetanus shot is necessary.