Dry, rough and cracked hands are serious, may be caused by ringworm, dry skin, hand eczema and other reasons, patients can improve the condition through general treatment, medication and other ways. 1. Ringworm: For patients with severe hand dryness, roughness and cracks caused by ringworm, they can use topical antifungal drugs such as clotrimazole, amorphophine, naftifine, etc.; keratinizing agents such as salicylic acid, etc., under the guidance of doctors, and oral itraconazole and fluconazole and other medicines can be used for systematic treatment. 2. Dry skin syndrome: patients should avoid frequent hand washing and long-term exposure to ultraviolet light, etc. Patients can use local moisturizers, such as urea ointment, glycerin, etc. for treatment to improve the situation of dry, rough and cracked hands. 3. Hand eczema: patients should avoid contact with allergens, reduce external stimuli, such as hot water scalding, violent scratching, excessive wiping, etc., to avoid eating irritating food. You can use topical medications, such as mupirocin ointment, flumethasone ointment, zinc oxide oil, etc. You can also take oral retinoic acid drugs, such as Avicenna, etc., in order to inhibit inflammatory reactions and improve the thickening of the stratum corneum. Hand dry rough cracks serious recommended that patients strictly follow the doctor’s instructions for medication, actively cooperate with the doctor’s treatment, pay attention to hand care in life, regular review and so on.