Multiple myeloma light chain type presenting with delirium can be treated by general treatment, medication, surgery and neurological complications causing delirium. 1. General treatment: it can be treated by actively lowering calcium through hydration, alkalization, etc. Drugs include sodium bicarbonate tablets, etc. 2. Drug therapy: chemotherapeutic drugs such as bortezomib, cyclophosphamide, etc. and glucocorticoid drugs such as dexamethasone can be used in combination for treatment. Adverse effects such as constipation and peripheral neuropathy should be noted. 3. Surgical treatment: autologous hematopoietic stem cell transplantation should be actively carried out after induction therapy, and allogeneic bone marrow transplantation can be considered after salvage therapy for recurrent refractory patients. 4. Complications causing delirium: it is necessary to find the cause of delirium, if it is caused by epilepsy, it is necessary to give antiepileptic treatment such as sodium valproate, and if it is caused by severe anemia, it is necessary to give suspension red blood cell transfusion in time. Multiple myeloma light chain type delirium is mostly considered to be caused by the invasion of tumor cells into the cranium, so multiple myeloma should be treated as soon as possible under the guidance of the physician after the diagnosis is clear to avoid serious delays in treatment.