Due to the imperfect development of various systems, preterm infants sometimes have some sequelae, such as cerebral palsy, etc., but timely care and treatment can reduce the occurrence of sequelae. Preterm infants should be breastfed as early as possible so that they can return to normal weight as early as possible; oxygen should be given to preterm infants with hypoxemia, but it should not be routinely given to preterm infants to prevent the high concentration of oxygen from leading to retinopathy of prematurity; hand washing should be strictly done when contacting newborn infants to prevent infections; and preterm infants should be injected with intramuscular Vitamin K for three days in a row in order to prevent the late onset of Vitamin K deficiency. Prevention of preterm labor is the key, and active management of preterm infants in the emergence of various complications is the key to reduce complications, sequelae, mortality of preterm infants, should actively cooperate with the doctor’s treatment to improve the quality of life.