Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum, and is a multifaceted and common disease. There are various factors in the formation of ulcers, among which the digestion of mucous membrane by acidic gastric juice is the basic factor in the formation of ulcers. The majority of ulcers occur in the duodenum and stomach, so they are also called gastric and duodenal ulcers. Factors such as excessive secretion of gastric acid, H. pylori infection and weakened protection of gastric mucosa are the main links that cause peptic ulcers. Of course, genetic factors, drug factors, environmental factors and mental factors are closely related to the occurrence of peptic ulcer. The clinical manifestations of peptic ulcers vary, typically presenting as chronic, periodic, rhythmic epigastric pain, with often insignificant signs. The most common examination method for clinical diagnosis of peptic ulcer is gastroscopy + mucosal biopsy. Barium meal X-ray can be considered for those who cannot tolerate gastroscopy, and Helicobacter pylori test, gastric fluid analysis and fecal occult blood test are important auxiliary examinations for peptic ulcer. Once a peptic ulcer is diagnosed, it should be treated promptly. Conventional treatment on the one hand is general treatment, including proper rest, work and rest, reasonable diet, regular life, quit bad habits, such as regular and quantitative meals, no overeating, less strong tea, strong coffee, avoid spicy and acidic stimulating food, quit smoking and alcohol, etc., while regulating emotions, avoid excessive tension and anxiety; on the other hand is drug therapy, such as inhibiting gastric acid secretion, such as cimetidine, ranitidine, Famotidine, omeprazole, rabeprazole, lansoprazole, triple therapy and quadruple therapy for H. pylori eradication, aluminum thioglycollate, bismuth potassium citrate, bismuth aluminate, etc. for gastric mucosa protection. The course of treatment is usually 6-8 weeks. Peptic ulcers that are not treated even though can cause a series of complications, such as bleeding, perforation, pyloric obstruction, and cancer. Once these complications occur, hospitalization should be immediately. In normal life, strengthening the mission, regular life, psychological health, reasonable diet, quit smoking and alcohol can help reduce the occurrence of peptic ulcer.