Autologous stem cell transplantation is a safer and effective treatment. Generally speaking, autologous stem cell transplantation involves pre-treatment before transplantation, infusion of stem cells and post-transplantation recovery, etc. Discomfort may occur in each process, but it is generally tolerable and no need to worry too much. 1. Before autologous stem cell transplantation, patients need to undergo pretreatment, which mainly adopts systemic irradiation, cytotoxic drugs and immunosuppressants. Some patients may have more serious clinical manifestations such as nausea, vomiting and diarrhea. After pretreatment, there is a myelosuppression period of about 2 weeks, at which time the patients may be combined with infections, fever and other diseases. 2. Re-infusion of stem cells: during the process of re-infusion, patients may have nausea, vomiting, coughing, dyspnea, red face, bradycardia and other uncomfortable reactions, and sometimes elevated blood pressure. 3. Post-transplantation rejection reaction: after autologous stem cell transplantation, patients may have rejection reactions, such as skin rash, vomiting and abnormal liver function. During autologous stem cell transplantation, certain discomfort may occur, but it is within the tolerable range of human beings, so there is no need to worry too much, and it is recommended to actively cooperate with the doctor’s treatment.