The dosage of glibenclamide tablets is: oral. Start 2.5mg before breakfast or once before breakfast and lunch, 1.25mg three times a day for mild cases, before three meals, and after 7 days incrementally 2.5mg per day.The usual dosage is 5-10mg per day, and the maximum dosage is not more than 15mg per day. This drug is a hypoglycemic drug, which inhibits hepatic glycogenolysis and glycogen isomerization by increasing the level of portal insulin or by direct action on the liver. Therefore, this drug is clinically applicable to mild and moderate type II diabetes mellitus that is not well controlled by diet alone; it is applicable to patients who have certain insulin secretion function of pancreatic islet β-cells and have no serious complications. There are adverse reactions such as headache, nausea, diarrhea, stomach pain, skin rash during the use of the drug. Type I diabetes mellitus is prohibited; type II diabetes mellitus with ketoacidosis, coma, severe burns, infections, trauma and major surgery and other stressful situations is prohibited; hepatic and renal insufficiency is prohibited; allergic to sulfonamides is prohibited. It should be used with caution in weak body, high fever, nausea and vomiting, hyperthyroidism and the elderly; blood glucose, urine glucose, urine ketone body, urine protein and liver and kidney function should be monitored regularly during the use of the drug, and eye examination should be conducted. If you need to use the drug, it should be used under the guidance of a specialist, not self-medication to avoid adverse reactions.