Ankylosing spondylitis B27 positive is more common, B27 negative, ankylosing spondylitis will be less likely, however, it also needs to be combined with the specific manifestations of a comprehensive judgment. Ankylosing spondylitis is an autoimmune disease, the cause of which is not well understood and may be related to certain infections. The typical manifestation of ankylosing spondylitis is lumbosacral pain and discomfort. Local CT examinations can reveal sacroiliac arthritis, and typical ankylosing spondylitis X-rays show bamboo-like changes in the spine. With the development of ankylosing spondylitis, the function of the spine will be gradually affected, such as bending and other activities will be limited. In the case of compulsory spondylitis, the treatment is mainly to give pain relief, such as non-steroidal painkillers such as Lofendene; try to control the condition with drugs such as immunosuppressants, there is no way to completely cure ankylosing spondylitis.