The difference between multiple and single colon polyps is the number as well as the risk of cancer. Colonic polyps are elevated lesions above the surrounding colonic mucosa and protrude into the intestinal lumen. They are usually asymptomatic, but sometimes abnormal bowel movements and bleeding may occur, and large polyps may lead to intestinal obstruction. Single and multiple polyps have different cancer risks, and multiple polyps have a higher chance of cancer than single polyps. Polyps without obvious symptoms need to be surgically removed as soon as possible to eliminate the risk of cancer. It is recommended to go to regular hospitals for examination and endoscopic resection as soon as possible to avoid delaying the condition and missing the best treatment period.