The danger period after pancreaticoduodenectomy is usually about 1 week. It can vary according to individual specifics, and some patients may also have life-threatening conditions such as hemorrhage within 1 to 2 weeks. 1. Acute danger is mainly intra-abdominal hemorrhage, which usually occurs within 48 hours after the operation, and is mainly caused by injuries during surgical operation, incomplete hemostasis, anastomotic bleeding, etc. If the amount of bleeding is small, pay close attention and observe the patient closely. If the amount of bleeding is small, pay attention to close observation; if the amount of bleeding is large, timely surgical exploration is needed. 2. Pancreaticoduodenectomy requires pancreatic-enteric anastomosis, biliary-enteric anastomosis, gastrointestinal anastomosis, etc. The healing time of anastomosis is usually about 1 week, and the anastomosis healing means that it basically passes the dangerous period. Anastomotic fistula, abdominal infection, can lead to systemic infection poisoning, sepsis, multi-organ failure, severe anastomotic fistula need a second operation. 3. pancreatic fistula produced by the pancreatic fluid corrosion of blood vessels to bleeding generally occur within 1 to 2 weeks after surgery, the serious cases can lead to life-threatening hemorrhage. If you consider the complications of cardiovascular and cerebrovascular accidents, the risk period may be longer. After pancreaticoduodenectomy, we need to closely observe the changes of the condition, and contact the doctor in time to find out the unexpected situation and deal with it in time.