The contraindications of Submerged Yang Seal Marrow Dan are not clear. It can be used to treat hypertension and cerebral arteriosclerosis with wind-fire incitement and kidney deficiency. Qian Yang Seal Marrow Dan is a formula of Zheng Qin’an, which is a combination of Qian Yang Dan and Seal Marrow Dan, and consists of epiphyllum, cypress, tortoise board, radix et rhizoma, roasted licorice, which has the efficacy of returning qi to the kidneys and restoring wind and submerging the yang, and can be used for the treatment of cerebral arteriosclerosis and hypertension that are caused by wind and fire, and renal insufficiency and lack of solidity. On the basis of Sealing Medulla Oblongata with submerged yang to replenish the earth and subdue the fire, it is added with Radix Polygoni Multiflori to warm yang, and Tortoise Plate to submerge yang in order to strengthen the effect of warming yang, submerging yang, and dense yang. Huangbai is cold and dry, which can clear dampness and heat in the lower Jiao, and licorice can harmonize the upper and lower parts of the body. The sweetness of licorice and the bitterness of Huangbai can transform the yin, and the sweetness of licorice and the pungency of sandalwood, the sweetness and pungency of licorice can transform the yang. Please consult the doctor promptly if you feel unwell, and do not use medicines on your own.