Walking ankle pain may be caused by chronic strain of the ankle joint, ankle sprain, osteoarthritis of the ankle, inflammatory disease of the ankle joint or gout. 1. Chronic strain of ankle joint: Because of long-term overstrain of ankle joint and excessive activities, such as dancing or ankle sports for a long time, chronic degeneration of ankle joint will easily occur, which will make the ankle joint painful during exertion. 2. Ankle sprains: Prolonged strenuous exercise can easily cause ligament sprains, which can lead to ankle pain. 3. Osteoarthritis of ankle: Osteoporosis of ankle, or chondritis, osteoarthritis, when the patient walks with repeated stimulation of the ankle area by external forces, will produce localized lesion pain, often accompanied by popping, or walking activities after the pain level increased significantly. 4. Inflammatory diseases of the ankle joint: rheumatism, rheumatoid arthritis, degenerative osteoarthritis, due to inflammation for a long time can also lead to ankle pain when walking. 5. Gout: Gout patients eat a lot of high-purine food, uric acid increase will appear when the joint pain, can be manifested as walking ankle pain.