Someone who takes twenty years of omeprazole is fine, it may be that the drug tolerance is high, or the symptoms are not obvious, but it is not recommended to take omeprazole for a long time. Long-term use of omeprazole without abnormalities, it may be that the drug tolerance is higher, or the symptoms of adverse reactions are not obvious, such as abdominal pain and diarrhea, gastrointestinal flatulence, nausea and vomiting, etc., usually mild, can disappear on their own, even if the long-term use of the drug has not seen serious adverse reactions. Omeprazole is an acid inhibiting drug, mainly used for duodenal ulcer, gastric ulcer, reflux esophagitis, stress ulcers, Zuo-Ai syndrome and other diseases. The drug is contraindicated in people who are allergic to omeprazole, infants and young children, and people with renal insufficiency. In case of dizziness, diarrhea, headache, nausea, bloating and other symptoms, it is recommended to stop using the drug and go to the hospital for examination.