In general, low-grade intraepithelial neoplasia is a type of precancerous lesion that requires treatment. When a colonoscopy is performed and low-grade intraepithelial neoplasia is detected, it is recommended to follow the doctor’s advice for further treatment. Endothelial neoplasia is subdivided into low-grade, intermediate-grade, and high-grade, which are precancerous lesions, with high-grade endothelial neoplasia having a relatively high rate of cancerous changes, while low-grade epithelial sarcomatoid lesions have a lower rate of cancerous changes. Although the cancer rate of low-grade epithelial sarcoma is lower than that of high-grade epithelial sarcoma, attention should be paid to it because it may become cancerous. Therefore, it is recommended to treat low-grade epithelial endothelial neoplasia once it is detected in order to avoid the adverse consequences of cancerous changes. When low-grade intraepithelial neoplasia is detected by colonoscopy, patients should be advised to seek early medical treatment for early diagnosis and treatment.