Before and after the application of the two drugs, it is necessary to conduct routine blood tests, liver and kidney function and lipid monitoring every half month to monitor the corresponding side effects, and men and women of childbearing age are instructed to avoid pregnancy and childbirth within six months to avoid teratogenic effects; 2. The treatment can be done with topical medication, such as topical application of ketocinone gel or peroxymethylphenidate gel; 3. Physical treatment can be done by red and blue light irradiation or helium-neon laser irradiation, or by Chinese medicine fire acupuncture.