If patients feel stuffy in the chest accompanied by inability to get up air, there are usually several factors as follows: 1. The most common factor is cardiogenic, for example, patients with coronary atherosclerotic heart disease, unstable angina, or arrhythmia, acute pericarditis, heart valve disease, and congenital heart disease will have symptoms of chest tightness and inability to get up air. 2. In some respiratory system diseases, such as chronic bronchitis, chronic bronchiectasis, chronic obstructive pulmonary emphysema, chronic pulmonary heart disease, and even pulmonary hypertension, there will also be symptoms and reactions of chest tightness and inability to get up air. 3. If there are endocrine metabolic diseases, including hyperthyroidism or thyroid dysfunction, hyperadrenocorticism, there will also be clinical symptoms of chest tightness and inability to get up air. 4. If there is acute food poisoning If acute food poisoning or harmful gas poisoning occurs, the symptoms of chest tightness and inability to get up air will also occur.