Vaginal swelling after the use of corkscrew in pregnant women is considered to be an inflammatory reaction caused by corkscrew irritation of local tissues. There are individual differences in the specific situation. Corkscrew is a stimulant medication that is generally used to relieve constipation, but not to cure it. Corkscrew should be used in moderation during pregnancy. Excessive use of Kerosene in pregnant women can cause strong contraction of local tissues, resulting in transient ischemia and inducing chronic inflammation. The main ingredients of Keserol are glycerin and sorbitol, and abuse can lead to patient dependence. In addition, during pregnancy, we should develop good defecation habits, eat more fresh fruits and vegetables and other dietary fiber-rich foods, and appropriate exercise can reduce the occurrence of constipation in pregnant women. It is recommended that pregnant women with severe constipation should use Kesiclofenac reasonably under the guidance of the doctor and actively cooperate with the doctor’s treatment.