The incidence of malignant melanoma has been increasing in recent years and varies greatly among different ethnic groups. Its pathological and biological features have attracted widespread attention in recent years. The mortality rate of malignant melanoma has been increasing in most countries in recent decades. Malignant melanoma occurs due to wind evil fighting with blood and Qi, which is born from changes; or blood in the veins, which is stagnant in the guard part, and Yang Qi binds; turbid Qi in the kidney mixes with Yang, which is caused by Yang Qi collection, and factors such as blood clotting and Qi stagnation. Reasons for high incidence of melanoma 1, frequent stimulation of pigmented nevi Melanoma and nevi have a certain correlation, 60% of malignant melanoma is malignant from pigmented nevi. Most of the malignant melanoma occurs due to the malignant transformation of the black pigmented nevus caused by repeated rubbing, scratching up and injury. Improper digging and drug erosion can transform the benign black pigmented nevus into malignant melanoma. 2.Related to endocrine The rapid development of malignant melanoma in women during pregnancy or childbearing age suggests that this disease is related to endocrine. 3. Prevalent in benign nevi It is reported that 84% of malignant melanoma comes from benign nevi. Wieeio reported that many patients did not notice the disease at the beginning because the moles were too small. It is believed that benign moles are the largest source of malignant melanoma. 4.Atmospheric pollution The massive emission of harmful substances such as Freon destroys the ozone layer, resulting in inadequate ultraviolet filtering. The harmful ultraviolet rays and harmful substances in the air work together on human skin, causing abnormal expression of melanocytes and triggering melanoma. Many people use a lot of chemical cosmetics in order to pursue clean and tender skin, resulting in chemical skin pollution, and some people even use chemical corrosives to remove moles on the skin, which is counterproductive and stimulates the excessive proliferation of melanocytes. 6.Lack of health knowledge The nevus that grows on the foot, perineum and other parts that are easy to be rubbed does not attract enough attention, and is squeezed and rubbed for a long time, which eventually leads to its malignant transformation. 7.Abuse of estrogen drugs There are estrogen receptors in the cells of malignant melanoma, so it is suspected that excess estrogen will stimulate the occurrence of melanoma. 8.Immunodeficiency With the improvement of living standard, Chinese people live significantly longer. Along with ageing, the immune function of the body gradually declines. Low immune function is one of the important reasons for the occurrence of melanoma, so the incidence of melanoma in the elderly is clinically high. 9.Benign melanotic plaques, i.e. nevi, of which junctional nevi are most likely to become malignant, mixed nevi are less likely to become malignant, and endothelial nevi are rarely malignant. However, most of the scalp melanomas are not transformed from nevi, so some people think that this disease is not completely related to nevi.