The severity of atherosclerosis is related to the location and degree of lesions, damage to the affected organs, and the presence or absence of complications, and cannot be generalized. Generally, it is more serious if it involves vital organs such as heart, brain and kidney, more serious if it causes severe stenosis or blockage, and more serious if it has already developed complications in organs such as heart and brain infarction. Aortic atherosclerosis can form aortic aneurysm, arterial dissection, once the vessel rupture, may endanger the patient’s life. Atherosclerosis of coronary arteries can easily cause myocardial ischemia or necrosis, and in severe cases, cardiogenic shock or sudden death may also occur. Atherosclerotic plaques in cranial arteries can cause vascular stenosis, insufficient cerebral blood supply, local thrombosis, plate rupture, cerebral embolism and other cerebrovascular accidents, and long-term chronic ischemia can develop into vascular dementia. Involvement of kidney, intestinal and lower limb blood vessels can cause serious consequences. For atherosclerosis, early preventive intervention should be done. If it has occurred, it should follow the doctor’s instructions to actively treat, prevent the development of lesions and strive for reversal, prolong the patient’s life and improve the quality of life.