Let’s find out what are the stages of Parkinson’s disease symptom development? At which stage is it best to receive pacemaker surgery? Parkinson’s disease can be divided into five stages according to the progression of symptoms: Stage 1: unilateral lesion only, unilateral hand tremor, foot tremor or stiffness, walking is not as sharp as usual, unstable in holding things; Stage 2: bilateral mild lesion, from unilateral lesion to bilateral, shaking of hands or even whole body, stiffness is aggravated, daily activities such as buttoning and holding chopsticks become difficult, poor sense of balance; Stage 3: bilateral lesion with early balance disorder. Difficulty in lifting legs, walking in small steps, easy to fall. Stage IV: severe lesions, often unconscious drooling, difficulty in swallowing, slow eating. Speech is slurred, expression is dull, face is expressionless, movement is difficult, and daily life is inseparable from family care; Stage V: Patients are confined to bed or wheelchair and cannot take care of themselves completely, some patients are only bedridden for a long time and cannot turn over on their own after being bedridden, and cannot take care of themselves completely in daily life. Parkinson’s disease is a chronic progressive disease and the timing of surgery is particularly important. Surgery is most appropriate after the honeymoon period of medication and when motor complications arise, which means that surgery is best when the disease has progressed to “stage 3”. Careful selection of patients with Parkinson’s disease in the early stages of the disease who have just developed motor complications will help to maximize the long-term benefits of pacemaker therapy after a team of physicians has fully evaluated the pros and cons of the patient.