Cholestasis in pregnant women is more harmful to the fetus, which can easily cause preterm labor, low-birth-weight babies, intrauterine distress, death of the fetus, and asphyxia of the newborn, therefore, clinically, once the itching of the skin in pregnant women occurs, they should go to the hospital for timely consultation in order to exclude the existence of cholestasis in pregnant women. For itching before the appearance of or before the rise in alanine aminotransferase, serum binding bile acid, if significantly elevated, clinically can basically consider the existence of this disease. Currently, there are no specific drugs for this disease, but in order to prevent postpartum hemorrhage, prenatal supplementation with vitamin K. In addition, obstetrical monitoring should be strengthened, the fetus should be observed dynamically, at least once a week, and labor should be induced after 37 weeks of gestation, and, in principle, should not exceed the expected date of delivery. During pregnancy or labor, if abnormalities of the fetal heart are detected or intrauterine distress of the fetus is suspected, cesarean section is required to end the labor urgently. And hormones should be contraindicated as induction of labor during pregnancy or post-partum rewarming. In case of jaundice or monitoring indicating fetal hypoxia, early hospitalization and, if necessary, timely termination of labor may be required to avoid hemorrhage.