In general, it is not recommended to drink alcohol 12 hours after taking roxithromycin capsules. The main component of roxithromycin capsule is roxithromycin, which belongs to macrolide class of drugs and is mainly metabolized and decomposed through human liver after entering human body. Alcohol should generally not be used simultaneously with cephalosporin antibiotics and nitroimidazole antibiotics, which may produce disulfiram-like reactions and a series of adverse reactions, such as chest tightness, shortness of breath, hypotension, etc., and even threaten life. Although the structure of roxithromycin does not contain methiodiazole group, drinking alcohol during its use may cause gastrointestinal reactions such as nausea and vomiting, reducing the safety of drug treatment. In addition, if roxithromycin capsules are consumed with alcohol, it will increase the metabolic burden on the liver, leading to liver insufficiency or even liver failure. In conclusion, since roxithromycin capsules are antibiotics, patients need to use them under the guidance of a doctor in order to better utilize the efficacy of the drug.