Drinking coffee absolutely can not take medicine, because coffee is rich in caffeine and caffeine, such substances will cause secondary failure of drugs, after drinking coffee resolutely can not take drugs orally, there are several categories: 1, the most common will produce secondary failure of drugs are antibiotics and anti-inflammatory drugs, such as levofloxacin, cephalosporin, penicillin, roxithromycin, azithromycin, such antibiotics can not be eaten after drinking coffee. 2, after drinking coffee can not take some traditional Chinese medicine, the blood tonic Chinese medicine, such as salvia, safflower, American ginseng, scutellaria, astragalus, angelica, gum and other drugs, will make the role of the blood tonic drugs greatly reduced, will make the pharmacokinetics and pharmacokinetics significantly reduced. 3, after drinking coffee can not eat to protect the gastric mucosa drugs, will make the stomach acid further reflux and reduce the absorption rate of gastric drugs, such as omeprazole, rabeprazole and other drugs, also can not eat after drinking coffee. 4, vitamins and trace elements of drugs can be taken after drinking coffee, but at intervals of more than 15 minutes.