Glucocorticoid is a steroid hormone secreted by the adrenal glands, and its effects on people in the body include many aspects, the effect on glucose metabolism can lead to an increase in blood sugar, the effect on lipid metabolism, glucocorticoid can rapidly activate lipolysis, the effect on water and electrolytes, patients with too much glucocorticoid usually have hypertension, another is the vasopressure effect, there is also glucocorticoid replacement After treatment, it can normalize the excretion of blood sodium, which may be related to atrial natriuretic peptide. Another one is the effect on inflammation and immunity. Glucocorticoids have significant immunosuppressive effects and are often used to control rejection after organ transplantation and in the treatment of autoimmune diseases. There are also effects on bones and connective tissues. Long-term glucocorticoid overdose can cause a decrease in bone mass, which is manifested by increased bone resorption, with the final clinical outcome being osteoporosis. Another is that it can affect the glucose metabolism of skeletal muscles, leading to steroidal diseases. Clinical applications are mainly in immunosuppression or for clinical hormone replacement therapy.