The causes of clear blisters on the buttocks include herpes simplex, chickenpox, eczema, etc. Targeted treatment is needed according to the cause. 1. Herpes simplex: caused by herpes simplex virus, characterized by clustered blisters, can cause the phenomenon of transparent blisters on the buttocks, the need for antiviral treatment, can be used externally with Penciclovir cream or glycerite lotion, secondary infection can be used externally with fusidic acid cream. 2. Chickenpox: caused by varicella zoster virus, the skin lesions are initially red spots, which gradually become papules and blisters, and need antiviral treatment, which can be applied with acyclovir cream or glycerol lotion, and fusidic acid cream can be applied externally in case of secondary infection. 3. Eczema: Patients with eczema may also have clear blisters on the buttocks, accompanied by itching. It can be treated with antipruritic drugs, such as topical zinc oxide lotion, glycerite lotion, etc. Oral antihistamine drugs, such as loratadine, cetirizine, etc., can be taken if necessary. It is recommended that when the phenomenon of transparent blisters on the buttocks to the hospital in time, to clarify the cause, follow the doctor’s instructions standardized treatment.